3h3d
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h3d RCSB], [http://www.ebi.ac.uk/pdbsum/3h3d PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h3d RCSB], [http://www.ebi.ac.uk/pdbsum/3h3d PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PUM_DROME PUM_DROME]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Required for abdominal development and to support proliferation and self-renewal of germ cells. Pum is the only gene required for nos activity that is not also required for posterior localization of germline determinants. Pum is required during embryogenesis when nos activity apparently moves anteriorly from the posterior pole.<ref>PMID:1459455</ref> <ref>PMID:1576962</ref> <ref>PMID:9660969</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 13:39, 24 December 2014
Drosophila Pumilio RNA binding domain (Puf domain)
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