2e6w
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2e6w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E6W FirstGlance]. <br> | <table><tr><td colspan='2'>[[2e6w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E6W FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DREAM, KCHIP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DREAM, KCHIP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e6w RCSB], [http://www.ebi.ac.uk/pdbsum/2e6w PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e6w RCSB], [http://www.ebi.ac.uk/pdbsum/2e6w PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSEN_HUMAN CSEN_HUMAN]] Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).<ref>PMID:9771752</ref> <ref>PMID:10078534</ref> <ref>PMID:10676964</ref> <ref>PMID:11259376</ref> <ref>PMID:11988022</ref> <ref>PMID:12829703</ref> Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface.<ref>PMID:9771752</ref> <ref>PMID:10078534</ref> <ref>PMID:10676964</ref> <ref>PMID:11259376</ref> <ref>PMID:11988022</ref> <ref>PMID:12829703</ref> May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.<ref>PMID:9771752</ref> <ref>PMID:10078534</ref> <ref>PMID:10676964</ref> <ref>PMID:11259376</ref> <ref>PMID:11988022</ref> <ref>PMID:12829703</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hajduk, P J | + | [[Category: Hajduk, P J]] |
| - | [[Category: Hebert, E | + | [[Category: Hebert, E]] |
| - | [[Category: Mendoza, R | + | [[Category: Mendoza, R]] |
| - | [[Category: Olejniczak, E T | + | [[Category: Olejniczak, E T]] |
| - | [[Category: Pereda-Lopez, A | + | [[Category: Pereda-Lopez, A]] |
| - | [[Category: Sun, C | + | [[Category: Sun, C]] |
| - | [[Category: Yu, L | + | [[Category: Yu, L]] |
[[Category: Calcium-bound form]] | [[Category: Calcium-bound form]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
Revision as of 13:50, 24 December 2014
Solution structure and calcium binding properties of EF-hands 3 and 4 of calsenilin
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