1a8b
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1A8B is a | + | 1A8B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and GPE as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: GPE. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A8B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: phospholipid analog]] | [[Category: phospholipid analog]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:04:27 2007'' |
Revision as of 10:59, 5 November 2007
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RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE
Overview
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as, annexins, protein kinase C, and certain coagulation proteins. Crystal, structures of Ca(2+)-annexin V complexes with phospholipid polar heads, provide molecular details of 'Ca(2+)-bridges' as key features in the, membrane attachment exhibited by these proteins. Distinct binding sites, for phospholipid head groups are observed, including a novel, double-Ca2+, recognition site for phosphoserine that may serve as a phosphatidylserine, receptor site in vivo.
About this Structure
1A8B is a Single protein structure of sequence from Rattus norvegicus with CA and GPE as ligands. Structure known Active Site: GPE. Full crystallographic information is available from OCA.
Reference
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670
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