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2jxx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXX FirstGlance]. <br> | <table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC2IP, NIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC2IP, NIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [http://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [http://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [http://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [http://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN]] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Butler, C | + | [[Category: Butler, C]] |
| - | [[Category: Dhe-Paganon, S | + | [[Category: Dhe-Paganon, S]] |
| - | [[Category: Doherty, R S | + | [[Category: Doherty, R S]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Fares, C | + | [[Category: Fares, C]] |
| - | [[Category: Karra, M | + | [[Category: Karra, M]] |
| - | [[Category: Lemak, A | + | [[Category: Lemak, A]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | [[Category: Srisailam, S]] | |
| - | [[Category: Srisailam, S | + | [[Category: Weigelt, J]] |
| - | [[Category: Weigelt, J | + | [[Category: Yee, A]] |
| - | [[Category: Yee, A | + | |
[[Category: Cytoplasmic 2-interacting protein]] | [[Category: Cytoplasmic 2-interacting protein]] | ||
[[Category: Methylation]] | [[Category: Methylation]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Nfat complex]] | [[Category: Nfat complex]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Nuclear factor of activated t-cell]] | [[Category: Nuclear factor of activated t-cell]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Ubiquitin like homologue]] | [[Category: Ubiquitin like homologue]] | ||
Revision as of 13:57, 24 December 2014
NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627
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Categories: Homo sapiens | Arrowsmith, C H | Butler, C | Dhe-Paganon, S | Doherty, R S | Edwards, A M | Fares, C | Karra, M | Lemak, A | Structural genomic | Srisailam, S | Weigelt, J | Yee, A | Cytoplasmic 2-interacting protein | Methylation | Nesg | Nfat complex | Nuclear factor of activated t-cell | Nucleus | Phosphoprotein | Protein binding | PSI, Protein structure initiative | Sgc | Ubiquitin like homologue
