4pmw
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pmw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pmw RCSB], [http://www.ebi.ac.uk/pdbsum/4pmw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pmw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pmw RCSB], [http://www.ebi.ac.uk/pdbsum/4pmw PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DI3L2_MOUSE DI3L2_MOUSE]] 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.<ref>PMID:23594738</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Faehnle, C R | + | [[Category: Faehnle, C R]] |
| - | [[Category: Joshua-Tor, L | + | [[Category: Joshua-Tor, L]] |
| - | [[Category: Walleshauser, J | + | [[Category: Walleshauser, J]] |
[[Category: Exonuclease]] | [[Category: Exonuclease]] | ||
[[Category: Hydrolase-rna complex]] | [[Category: Hydrolase-rna complex]] | ||
Revision as of 13:57, 24 December 2014
Structure of mouse Dis3L2 in complex with oligoU RNA substrate
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