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1i1r
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1i1r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I1R FirstGlance]. <br> | <table><tr><td colspan='2'>[[1i1r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I1R FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i1r RCSB], [http://www.ebi.ac.uk/pdbsum/1i1r PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i1r RCSB], [http://www.ebi.ac.uk/pdbsum/1i1r PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN]] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human herpesvirus 8]] | [[Category: Human herpesvirus 8]] | ||
| - | [[Category: Chow, D | + | [[Category: Chow, D]] |
| - | [[Category: Garcia, K C | + | [[Category: Garcia, K C]] |
| - | [[Category: He, X | + | [[Category: He, X]] |
| - | [[Category: Rose-John, S | + | [[Category: Rose-John, S]] |
| - | [[Category: Snow, A L | + | [[Category: Snow, A L]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Cytokine-receptor complex]] | [[Category: Cytokine-receptor complex]] | ||
[[Category: Gp130]] | [[Category: Gp130]] | ||
[[Category: Viral il-6]] | [[Category: Viral il-6]] | ||
Revision as of 13:59, 24 December 2014
CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX
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