3cr0
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cr0 RCSB], [http://www.ebi.ac.uk/pdbsum/3cr0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cr0 RCSB], [http://www.ebi.ac.uk/pdbsum/3cr0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/WEE1_HUMAN WEE1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
| - | [[Category: Baker, E N | + | [[Category: Baker, E N]] |
| - | [[Category: Squire, C J | + | [[Category: Squire, C J]] |
[[Category: Inhibitor complex]] | [[Category: Inhibitor complex]] | ||
[[Category: Kinase domain]] | [[Category: Kinase domain]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 14:10, 24 December 2014
Wee1 kinase complex with inhibitor PD259_809
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