1f2s

From Proteopedia

(Difference between revisions)

Revision as of 14:11, 24 December 2014

CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION

Structural highlights

1f2s is a 2 chain structure with sequence from Bos taurus and Momordica charantia. This structure supersedes the now removed PDB entry 1mcu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	1mct
Activity:	Trypsin, with EC number 3.4.21.4
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[ITR2_MOMCH] Inhibits trypsin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The stoichiometric complex formed between bovine beta-trypsin and Momordica charantia, Linn. Cucurbitaceae trypsin inhibitor A (MCTI-A) was crystallized and its X-ray crystal structure was refined to a final R value of 0.179 using data of 7.0- to 1.8-A resolution. Combination with results on the complex of MCTI-A with porcine trypsin gives the sequence of MCTI-A definitely, of which 13 residues are conserved compared with other squash family trypsin inhibitors. Its spatial structure and the conformation of its primary binding segment from Cys3I (P3) to Glu7I (P3'), which contains a reactive scissile bond Arg5I C-Ile6I N, were found to be very similar to the other squash family proteinase inhibitors.

Crystal structure of the complex formed between bovine beta-trypsin and MCTI-A, a trypsin inhibitor of squash family, at 1.8-A resolution.,Zhu Y, Huang Q, Qian M, Jia Y, Tang Y J Protein Chem. 1999 Jul;18(5):505-9. PMID:10524768^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zhu Y, Huang Q, Qian M, Jia Y, Tang Y. Crystal structure of the complex formed between bovine beta-trypsin and MCTI-A, a trypsin inhibitor of squash family, at 1.8-A resolution. J Protein Chem. 1999 Jul;18(5):505-9. PMID:10524768

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f2s"

@@ Line 8: / Line 8: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f2s RCSB], [http://www.ebi.ac.uk/pdbsum/1f2s PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ITR2_MOMCH ITR2_MOMCH]] Inhibits trypsin.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1f2s

From Proteopedia

Revision as of 14:11, 24 December 2014

CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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