2bo2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bo2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BO2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2bo2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BO2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bou|2bou]], [[2box|2box]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bou|2bou]], [[2box|2box]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bo2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bo2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Abbott, R J.M | + | [[Category: Abbott, R J.M]] |
| - | [[Category: Handford, P A | + | [[Category: Handford, P A]] |
| - | [[Category: Knott, V | + | [[Category: Knott, V]] |
| - | [[Category: Lea, S M | + | [[Category: Lea, S M]] |
| - | [[Category: Mcdonnell, J M | + | [[Category: Mcdonnell, J M]] |
| - | [[Category: Roversi, P | + | [[Category: Roversi, P]] |
| - | [[Category: Spendlove, I | + | [[Category: Spendlove, I]] |
| - | [[Category: Teriete, P | + | [[Category: Teriete, P]] |
| - | + | ||
[[Category: Calcium-binding]] | [[Category: Calcium-binding]] | ||
[[Category: Cd55]] | [[Category: Cd55]] | ||
Revision as of 14:25, 24 December 2014
EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH CALCIUM.
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