4afl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4afl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AFL FirstGlance]. <br> | <table><tr><td colspan='2'>[[4afl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AFL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vnf|2vnf]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vnf|2vnf]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4afl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4afl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4afl RCSB], [http://www.ebi.ac.uk/pdbsum/4afl PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4afl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4afl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4afl RCSB], [http://www.ebi.ac.uk/pdbsum/4afl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ING4_HUMAN ING4_HUMAN]] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).<ref>PMID:12750254</ref> <ref>PMID:15251430</ref> <ref>PMID:15029197</ref> <ref>PMID:15528276</ref> <ref>PMID:15897452</ref> <ref>PMID:16387653</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Blanco, F J | + | [[Category: Blanco, F J]] |
| - | [[Category: Culurgioni, S | + | [[Category: Culurgioni, S]] |
| - | [[Category: Montoya, G | + | [[Category: Montoya, G]] |
| - | [[Category: Moreno, A | + | [[Category: Moreno, A]] |
| - | [[Category: Munoz, I G | + | [[Category: Munoz, I G]] |
| - | [[Category: Palacios, A | + | [[Category: Palacios, A]] |
| - | [[Category: Palmero, I | + | [[Category: Palmero, I]] |
| - | [[Category: Villate, M | + | [[Category: Villate, M]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Chromatin remodelling]] | [[Category: Chromatin remodelling]] | ||
[[Category: Tumour suppressor]] | [[Category: Tumour suppressor]] | ||
Revision as of 14:29, 24 December 2014
The crystal structure of the ING4 dimerization domain reveals the functional organization of the ING family of chromatin binding proteins.
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