2pso

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<StructureSection load='2pso' size='340' side='right' caption='[[2pso]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2pso' size='340' side='right' caption='[[2pso]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2pso]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSO OCA]. <br>
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<table><tr><td colspan='2'>[[2pso]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PSO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STARD13, DLC2, GT650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STARD13, DLC2, GT650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pso RCSB], [http://www.ebi.ac.uk/pdbsum/2pso PDBsum]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pso RCSB], [http://www.ebi.ac.uk/pdbsum/2pso PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[[http://www.uniprot.org/uniprot/STA13_HUMAN STA13_HUMAN]] GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.<ref>PMID:14697242</ref> <ref>PMID:16217026</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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Comparative structural analysis of lipid binding START domains.,Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schuler H, Lehtio L PLoS One. 2011;6(6):e19521. Epub 2011 Jun 30. PMID:21738568<ref>PMID:21738568</ref>
Comparative structural analysis of lipid binding START domains.,Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schuler H, Lehtio L PLoS One. 2011;6(6):e19521. Epub 2011 Jun 30. PMID:21738568<ref>PMID:21738568</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Berg, S Van den.]]
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[[Category: Berg, S Van den]]
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[[Category: Berglund, H.]]
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[[Category: Berglund, H]]
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[[Category: Busam, R.]]
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[[Category: Busam, R]]
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[[Category: Collins, R.]]
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[[Category: Collins, R]]
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[[Category: Dahlgren, L G.]]
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[[Category: Dahlgren, L G]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Flodin, S.]]
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[[Category: Flodin, S]]
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[[Category: Flores, A.]]
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[[Category: Flores, A]]
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[[Category: Graslund, S.]]
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[[Category: Graslund, S]]
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[[Category: Hallberg, B M.]]
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[[Category: Hallberg, B M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hammarstrom, M]]
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[[Category: Holmberg-Schiavone, L.]]
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[[Category: Holmberg-Schiavone, L]]
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[[Category: Johansson, I.]]
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[[Category: Johansson, I]]
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[[Category: Kallas, A.]]
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[[Category: Kallas, A]]
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[[Category: Karlberg, T.]]
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[[Category: Karlberg, T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotenyova, T]]
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[[Category: Lehtio, L.]]
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[[Category: Lehtio, L]]
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[[Category: Moche, M.]]
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[[Category: Moche, M]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund, P]]
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[[Category: Nyman, T.]]
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[[Category: Nyman, T]]
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[[Category: Ogg, D.]]
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[[Category: Ogg, D]]
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[[Category: Persson, C.]]
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[[Category: Persson, C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Sagemark, J.]]
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[[Category: Sagemark, J]]
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[[Category: Stenmark, P.]]
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[[Category: Stenmark, P]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom, M]]
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[[Category: Thorsell, A G.]]
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[[Category: Thorsell, A G]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: Welin, M.]]
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[[Category: Welin, M]]
[[Category: Alpha and beta protein]]
[[Category: Alpha and beta protein]]
[[Category: Helix swapping]]
[[Category: Helix swapping]]
[[Category: Lipid binding]]
[[Category: Lipid binding]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Unknown function]]
[[Category: Unknown function]]

Revision as of 14:31, 24 December 2014

Human StarD13 (DLC2) lipid transfer and protein localization domain

2pso, resolution 2.80Å

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OCA

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