1x9l
From Proteopedia
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| - | [[Image:1x9l.gif|left|200px]] | + | [[Image:1x9l.gif|left|200px]] |
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| - | '''Solution structure of CuI-DR1885 from Deinococcus Radiodurans''' | + | {{Structure |
| + | |PDB= 1x9l |SIZE=350|CAPTION= <scene name='initialview01'>1x9l</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CU1:COPPER (I) ION'>CU1</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of CuI-DR1885 from Deinococcus Radiodurans''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1X9L is a [ | + | 1X9L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9L OCA]. |
==Reference== | ==Reference== | ||
| - | A copper(I) protein possibly involved in the assembly of CuA center of bacterial cytochrome c oxidase., Banci L, Bertini I, Ciofi-Baffoni S, Katsari E, Katsaros N, Kubicek K, Mangani S, Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3994-9. Epub 2005 Mar 7. PMID:[http:// | + | A copper(I) protein possibly involved in the assembly of CuA center of bacterial cytochrome c oxidase., Banci L, Bertini I, Ciofi-Baffoni S, Katsari E, Katsaros N, Kubicek K, Mangani S, Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3994-9. Epub 2005 Mar 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15753304 15753304] |
[[Category: Deinococcus radiodurans r1]] | [[Category: Deinococcus radiodurans r1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: CU1]] | [[Category: CU1]] | ||
[[Category: copper binding protein]] | [[Category: copper binding protein]] | ||
| - | [[Category: deinococcus | + | [[Category: deinococcus radioduran]] |
[[Category: holo-form]] | [[Category: holo-form]] | ||
[[Category: nmr]] | [[Category: nmr]] | ||
[[Category: solution structure]] | [[Category: solution structure]] | ||
[[Category: spine]] | [[Category: spine]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:06:54 2008'' |
Revision as of 13:06, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of CuI-DR1885 from Deinococcus Radiodurans
Overview
Sco1 and Cox17 are accessory proteins required for the correct assembly of eukaryotic cytochrome c oxidase. At variance with Sco1, Cox17 orthologs are found only in eukaryotes. We browsed bacterial genomes to search proteins functionally equivalent to Cox17, and we identified a class of proteins of unknown function displaying a conserved gene neighborhood to bacterial Sco1 genes, all sharing a potential metal binding motif H(M)X10MX21HXM. Two members of this group, DR1885 from Deinococcus radiodurans and CC3502 from Caulobacter crescentus, were expressed, and their interaction with copper was investigated. The solution structure and extended x-ray absorption fine structure data on the former protein reveal that the protein binds copper(I) through a histidine and three Mets in a cupredoxin-like fold. The surface location of the copper-binding site as well as the type of coordination are well poised for metal transfer chemistry, suggesting that DR1885 might transfer copper, taking the role of Cox17 in bacteria. On the basis of our results, a possible pathway for copper delivery to the Cu(A) center in bacteria is proposed.
About this Structure
1X9L is a Single protein structure of sequence from Deinococcus radiodurans r1. Full crystallographic information is available from OCA.
Reference
A copper(I) protein possibly involved in the assembly of CuA center of bacterial cytochrome c oxidase., Banci L, Bertini I, Ciofi-Baffoni S, Katsari E, Katsaros N, Kubicek K, Mangani S, Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3994-9. Epub 2005 Mar 7. PMID:15753304
Page seeded by OCA on Thu Mar 20 15:06:54 2008
Categories: Deinococcus radiodurans r1 | Single protein | Banci, L. | Bertini, I. | Ciofi-Baffoni, S. | Katsari, E. | Katsaros, N. | Kubicek, K. | SPINE, Structural Proteomics in Europe. | CU1 | Copper binding protein | Deinococcus radioduran | Holo-form | Nmr | Solution structure | Spine | Structural genomic | Structural proteomics in europe
