1xax
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1xax.gif|left|200px]] | + | [[Image:1xax.gif|left|200px]] |
| - | + | ||
| - | '''NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae''' | + | {{Structure |
| + | |PDB= 1xax |SIZE=350|CAPTION= <scene name='initialview01'>1xax</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1XAX is a [ | + | 1XAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAX OCA]. |
==Reference== | ==Reference== | ||
| - | NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae, and comparison with the X-ray structure of an Aquifex aeolicus homolog., Yeh DC, Parsons LM, Parsons JF, Liu F, Eisenstein E, Orban J, Protein Sci. 2005 Feb;14(2):424-30. Epub 2005 Jan 4. PMID:[http:// | + | NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae, and comparison with the X-ray structure of an Aquifex aeolicus homolog., Yeh DC, Parsons LM, Parsons JF, Liu F, Eisenstein E, Orban J, Protein Sci. 2005 Feb;14(2):424-30. Epub 2005 Jan 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15632286 15632286] |
[[Category: Haemophilus influenzae]] | [[Category: Haemophilus influenzae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 26: | Line 35: | ||
[[Category: protein structure initiative]] | [[Category: protein structure initiative]] | ||
[[Category: s2f]] | [[Category: s2f]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structure 2 function project]] | [[Category: structure 2 function project]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:07:22 2008'' |
Revision as of 13:07, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae
Overview
The solution structure of the 154-residue conserved hypothetical protein HI0004 has been determined using multidimensional heteronuclear NMR spectroscopy. HI0004 has sequence homologs in many organisms ranging from bacteria to humans and is believed to be essential in Haemophilus influenzae, although an exact function has yet to be defined. It has a alpha-beta-alpha sandwich architecture consisting of a central four-stranded beta-sheet with the alpha2-helix packed against one side of the beta-sheet and four alpha-helices (alpha1, alpha3, alpha4, alpha5) on the other side. There is structural homology with the eukaryotic matrix metalloproteases (MMPs), but little sequence similarity except for a conserved region containing three histidines that appears in both the MMPs and throughout the HI0004 family of proteins. The solution structure of HI0004 is compared with the X-ray structure of an Aquifex aeolicus homolog, AQ_1354, which has 36% sequence identity over 148 residues. Despite this level of sequence homology, significant differences exist between the two structures. These differences are described along with possible functional implications of the structures.
About this Structure
1XAX is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.
Reference
NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae, and comparison with the X-ray structure of an Aquifex aeolicus homolog., Yeh DC, Parsons LM, Parsons JF, Liu F, Eisenstein E, Orban J, Protein Sci. 2005 Feb;14(2):424-30. Epub 2005 Jan 4. PMID:15632286
Page seeded by OCA on Thu Mar 20 15:07:22 2008
