1y3a
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y3a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3A FirstGlance]. <br> | <table><tr><td colspan='2'>[[1y3a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3A FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y3a RCSB], [http://www.ebi.ac.uk/pdbsum/1y3a PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y3a RCSB], [http://www.ebi.ac.uk/pdbsum/1y3a PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Blaesius, R | + | [[Category: Blaesius, R]] |
| - | [[Category: Bodor, E T | + | [[Category: Bodor, E T]] |
| - | [[Category: Fredericks, Z | + | [[Category: Fredericks, Z]] |
| - | [[Category: Harden, T K | + | [[Category: Harden, T K]] |
| - | [[Category: Jezyk, M R | + | [[Category: Jezyk, M R]] |
| - | [[Category: Johnston, C A | + | [[Category: Johnston, C A]] |
| - | [[Category: Jones, M B | + | [[Category: Jones, M B]] |
| - | [[Category: Ramer, J K | + | [[Category: Ramer, J K]] |
| - | [[Category: Siderovski, D P | + | [[Category: Siderovski, D P]] |
| - | [[Category: Sondek, J | + | [[Category: Sondek, J]] |
| - | [[Category: Watts, V J | + | [[Category: Watts, V J]] |
| - | [[Category: Willard, F S | + | [[Category: Willard, F S]] |
[[Category: Protein-peptide complex]] | [[Category: Protein-peptide complex]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 14:46, 24 December 2014
Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
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