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4l4r
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l4r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L4R FirstGlance]. <br> | <table><tr><td colspan='2'>[[4l4r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L4R FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l4s|4l4s]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l4s|4l4s]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l4r RCSB], [http://www.ebi.ac.uk/pdbsum/4l4r PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l4r RCSB], [http://www.ebi.ac.uk/pdbsum/4l4r PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref> | [[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref> | ||
| - | == Function == | ||
| - | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.,Dempster S, Harper S, Moses JE, Dreveny I Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1484-90. doi:, 10.1107/S1399004714005422. Epub 2014 Apr 30. PMID:24816116<ref>PMID:24816116</ref> | Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.,Dempster S, Harper S, Moses JE, Dreveny I Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1484-90. doi:, 10.1107/S1399004714005422. Epub 2014 Apr 30. PMID:24816116<ref>PMID:24816116</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: L-lactate dehydrogenase]] | [[Category: L-lactate dehydrogenase]] | ||
| - | [[Category: Dempster, S | + | [[Category: Dempster, S]] |
| - | [[Category: Dreveny, I | + | [[Category: Dreveny, I]] |
| - | [[Category: Harper, S | + | [[Category: Harper, S]] |
| - | [[Category: Moses, J E | + | [[Category: Moses, J E]] |
[[Category: Anaerobic respiration]] | [[Category: Anaerobic respiration]] | ||
[[Category: Glycolysis]] | [[Category: Glycolysis]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 14:49, 24 December 2014
Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme
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