1xed
From Proteopedia
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| - | [[Image:1xed.jpg|left|200px]] | + | [[Image:1xed.jpg|left|200px]] |
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| - | '''Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR''' | + | {{Structure |
| + | |PDB= 1xed |SIZE=350|CAPTION= <scene name='initialview01'>1xed</scene>, resolution 1.90Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= PIGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XED is a [ | + | 1XED is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XED OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor., Hamburger AE, West AP Jr, Bjorkman PJ, Structure. 2004 Nov;12(11):1925-35. PMID:[http:// | + | Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor., Hamburger AE, West AP Jr, Bjorkman PJ, Structure. 2004 Nov;12(11):1925-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15530357 15530357] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ig-like fold]] | [[Category: ig-like fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:08:42 2008'' |
Revision as of 13:08, 20 March 2008
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| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | PIGR (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR
Contents |
Overview
The polymeric immunoglobulin receptor (pIgR) is a type I transmembrane protein that delivers dimeric IgA (dIgA) and pentameric IgM to mucosal secretions. Here, we report the 1.9 A resolution X-ray crystal structure of the N-terminal domain of human pIgR, which binds dIgA in the absence of other pIgR domains with an equilibrium dissociation constant of 300 nM. The structure of pIgR domain 1 reveals a folding topology similar to immunoglobulin variable domains, but with differences in the counterparts of the complementarity determining regions (CDRs), including a helical turn in CDR1 and a CDR3 loop that points away from the other CDRs. The unusual CDR3 loop position prevents dimerization analogous to the pairing of antibody variable heavy and variable light domains. The pIgR domain 1 structure allows interpretation of previous mutagenesis results and structure-based comparisons between pIgR and other IgA receptors.
Disease
Known disease associated with this structure: IgA nephropathy, susceptibility to OMIM:[173880]
About this Structure
1XED is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor., Hamburger AE, West AP Jr, Bjorkman PJ, Structure. 2004 Nov;12(11):1925-35. PMID:15530357
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