1xeu

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[[Image:1xeu.gif|left|200px]]<br /><applet load="1xeu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1xeu.gif|left|200px]]
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caption="1xeu, resolution 2.05&Aring;" />
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'''Crystal Structure of Internalin C from Listeria monocytogenes'''<br />
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{{Structure
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|PDB= 1xeu |SIZE=350|CAPTION= <scene name='initialview01'>1xeu</scene>, resolution 2.05&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= inlC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1639 Listeria monocytogenes])
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}}
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'''Crystal Structure of Internalin C from Listeria monocytogenes'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1XEU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEU OCA].
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1XEU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEU OCA].
==Reference==
==Reference==
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Structure of internalin C from Listeria monocytogenes., Ooi A, Hussain S, Seyedarabi A, Pickersgill RW, Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1287-93. Epub 2006, Oct 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17057330 17057330]
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Structure of internalin C from Listeria monocytogenes., Ooi A, Hussain S, Seyedarabi A, Pickersgill RW, Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1287-93. Epub 2006, Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057330 17057330]
[[Category: Listeria monocytogenes]]
[[Category: Listeria monocytogenes]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: listeria monocytogenes; cellular invasion; internalin c; leucine-rich repeat; crystal structure]]
[[Category: listeria monocytogenes; cellular invasion; internalin c; leucine-rich repeat; crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:54:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:08:56 2008''

Revision as of 13:08, 20 March 2008


PDB ID 1xeu

Drag the structure with the mouse to rotate
, resolution 2.05Å
Gene: inlC (Listeria monocytogenes)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Internalin C from Listeria monocytogenes


Overview

The crystal structure of internalin C (InlC) from Listeria monocytogenes has been determined at 2.0 A resolution. Several observations implicate InlC in infection: inlC has the same transcriptional activator as other virulence genes, it is only present in pathogenic Listeria strains and an inlC deletion mutant is significantly less virulent. While the extended concave receptor-binding surfaces of the leucine-rich repeat (LRR) domains of internalins A and B have aromatic clusters involved in receptor binding, the corresponding surface of InlC is smaller, flatter and more hydrophilic, suggesting that InlC may be involved in weak or transient associations with receptors; this may help explain why no receptor has yet been discovered for InlC. In contrast, the Ig-like domain, to which the LRR domain is fused, has surface aromatics that may be of functional importance, possibly being involved in binding to the surface of the bacteria or in receptor binding.

About this Structure

1XEU is a Single protein structure of sequence from Listeria monocytogenes. Full crystallographic information is available from OCA.

Reference

Structure of internalin C from Listeria monocytogenes., Ooi A, Hussain S, Seyedarabi A, Pickersgill RW, Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1287-93. Epub 2006, Oct 18. PMID:17057330

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