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4uxv

From Proteopedia

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Revision as of 15:01, 24 December 2014

Cytoplasmic domain of bacterial cell division protein EzrA

Structural highlights

4uxv is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	4uy3
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[EZRA_BACSU] Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.

Publication Abstract from PubMed

Bacterial cell division is facilitated by a molecular machine-the divisome-that assembles at mid-cell in dividing cells. The formation of the cytokinetic Z-ring by the tubulin homologue FtsZ is regulated by several factors, including the divisome component EzrA. Here we describe the structure of the 60-kDa cytoplasmic domain of EzrA, which comprises five linear repeats of an unusual triple helical bundle. The EzrA structure is bent into a semicircle, providing the protein with the potential to interact at both N- and C-termini with adjacent membrane-bound divisome components. We also identify at least two binding sites for FtsZ on EzrA and map regions of EzrA that are responsible for regulating FtsZ assembly. The individual repeats, and their linear organization, are homologous to the spectrin proteins that connect actin filaments to the membrane in eukaryotes, and we thus propose that EzrA is the founding member of the bacterial spectrin family.

Structure and function of a spectrin-like regulator of bacterial cytokinesis.,Cleverley RM, Barrett JR, Basle A, Bui NK, Hewitt L, Solovyova A, Xu ZQ, Daniel RA, Dixon NE, Harry EJ, Oakley AJ, Vollmer W, Lewis RJ Nat Commun. 2014 Nov 18;5:5421. doi: 10.1038/ncomms6421. PMID:25403286^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cleverley RM, Barrett JR, Basle A, Bui NK, Hewitt L, Solovyova A, Xu ZQ, Daniel RA, Dixon NE, Harry EJ, Oakley AJ, Vollmer W, Lewis RJ. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nat Commun. 2014 Nov 18;5:5421. doi: 10.1038/ncomms6421. PMID:25403286 doi:http://dx.doi.org/10.1038/ncomms6421

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4uxv"

@@ Line 6: / Line 6: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxv RCSB], [http://www.ebi.ac.uk/pdbsum/4uxv PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/EZRA_BACSU EZRA_BACSU]] Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

4uxv

From Proteopedia

Revision as of 15:01, 24 December 2014

Cytoplasmic domain of bacterial cell division protein EzrA

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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