3quk

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[[Image:3quk.png|left|200px]]
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==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4A)==
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<StructureSection load='3quk' size='340' side='right' caption='[[3quk]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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{{STRUCTURE_3quk| PDB=3quk | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3quk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUK FirstGlance]. <br>
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===Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4A)===
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[3qul|3qul]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3quk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3quk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3quk RCSB], [http://www.ebi.ac.uk/pdbsum/3quk PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[3quk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUK OCA].
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== Function ==
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[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Major histocompatibility complex|Major histocompatibility complex]]
*[[Major histocompatibility complex|Major histocompatibility complex]]
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__TOC__
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</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Achour, A.]]
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[[Category: Achour, A]]
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[[Category: Allerbring, E.]]
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[[Category: Allerbring, E]]
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[[Category: Duru, A D.]]
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[[Category: Duru, A D]]
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[[Category: Friemann, R.]]
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[[Category: Friemann, R]]
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[[Category: Grimm, S.]]
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[[Category: Grimm, S]]
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[[Category: Madhurantakam, C.]]
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[[Category: Madhurantakam, C]]
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[[Category: Mazumdar, P A.]]
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[[Category: Mazumdar, P A]]
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[[Category: Nygren, P.]]
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[[Category: Nygren, P]]
[[Category: Sandalova, T]]
[[Category: Sandalova, T]]
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[[Category: Spetz, A.]]
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[[Category: Spetz, A]]
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[[Category: Tomek, M B.]]
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[[Category: Tomek, M B]]
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[[Category: Uchtenhagen, H.]]
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[[Category: Uchtenhagen, H]]
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[[Category: Uhlin, M.]]
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[[Category: Uhlin, M]]
[[Category: Beta2-microglobulin]]
[[Category: Beta2-microglobulin]]
[[Category: Cell surface]]
[[Category: Cell surface]]

Revision as of 15:01, 24 December 2014

Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4A)

3quk, resolution 2.41Å

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