2ks4

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ks4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ks4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ks4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ks4 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ks4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ks4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ks4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ks4 PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ACTP1_STOHE ACTP1_STOHE]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Stichodactyla helianthus]]
[[Category: Stichodactyla helianthus]]
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[[Category: Bruix, M.]]
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[[Category: Bruix, M]]
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[[Category: Castrillo, I.]]
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[[Category: Castrillo, I]]
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[[Category: Santoro, J.]]
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[[Category: Santoro, J]]
[[Category: Cytolysis]]
[[Category: Cytolysis]]
[[Category: Hemolysis]]
[[Category: Hemolysis]]

Revision as of 15:05, 24 December 2014

NMR structure of the sea anemone actinoporin Sticholysin

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