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1un2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1un2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dyv 1dyv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UN2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1un2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dyv 1dyv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UN2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a23|1a23]], [[1a24|1a24]], [[1a2j|1a2j]], [[1a2l|1a2l]], [[1a2m|1a2m]], [[1ac1|1ac1]], [[1acv|1acv]], [[1bq7|1bq7]], [[1dsb|1dsb]], [[1fvj|1fvj]], [[1fvk|1fvk]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a23|1a23]], [[1a24|1a24]], [[1a2j|1a2j]], [[1a2l|1a2l]], [[1a2m|1a2m]], [[1ac1|1ac1]], [[1acv|1acv]], [[1bq7|1bq7]], [[1dsb|1dsb]], [[1fvj|1fvj]], [[1fvk|1fvk]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1un2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1un2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1un2 RCSB], [http://www.ebi.ac.uk/pdbsum/1un2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1un2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1un2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1un2 RCSB], [http://www.ebi.ac.uk/pdbsum/1un2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Glockshuber, R | + | [[Category: Glockshuber, R]] |
| - | [[Category: Heinemann, U | + | [[Category: Heinemann, U]] |
| - | [[Category: Hennecke, J | + | [[Category: Hennecke, J]] |
| - | [[Category: Manjasetty, B A | + | [[Category: Manjasetty, B A]] |
[[Category: Circular permutation]] | [[Category: Circular permutation]] | ||
[[Category: Disulfide bond formation]] | [[Category: Disulfide bond formation]] | ||
Revision as of 15:12, 24 December 2014
CRYSTAL STRUCTURE OF CIRCULARLY PERMUTED CPDSBA_Q100T99 PRESERVED GLOBAL FOLD AND LOCAL STRUCTURAL ADJUSTMENTS
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