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3mlp

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{{STRUCTURE_3mlp| PDB=3mlp | SCENE= }}
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==Early B-cell Factor 1 (Ebf1) bound to DNA==
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===Early B-cell Factor 1 (Ebf1) bound to DNA===
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<StructureSection load='3mlp' size='340' side='right' caption='[[3mlp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20876732}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mlp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MLP FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mln|3mln]], [[3mlo|3mlo]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ebf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mlp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mlp RCSB], [http://www.ebi.ac.uk/pdbsum/3mlp PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/COE1_MOUSE COE1_MOUSE]] Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.<ref>PMID:20876732</ref>
[[http://www.uniprot.org/uniprot/COE1_MOUSE COE1_MOUSE]] Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.<ref>PMID:20876732</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Early B-cell factor 1 (Ebf1) is a key transcriptional determinant of B-lymphocyte differentiation whose DNA-binding domain has no sequence similarity to other transcription factor families. Here we report the crystal structure of an Ebf1 dimer bound to its palindromic recognition site. The DNA-binding domain adopts a pseudoimmunoglobulin-like fold with novel topology, but is structurally similar to the Rel homology domains of NFAT and NF-kappaB. Ebf1 contacts the DNA with two loop-based modules and a unique Zn coordination motif whereby each Ebf1 monomer interacts with both palindromic half-sites. This unusual mode of DNA recognition generates an extended contact area that may be crucial for the function of Ebf1 in chromatin.
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==About this Structure==
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Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins.,Treiber N, Treiber T, Zocher G, Grosschedl R Genes Dev. 2010 Oct 15;24(20):2270-5. Epub 2010 Sep 28. PMID:20876732<ref>PMID:20876732</ref>
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[[3mlp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020876732</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
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[[Category: Grosschedl, R.]]
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[[Category: Grosschedl, R]]
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[[Category: Treiber, N.]]
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[[Category: Treiber, N]]
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[[Category: Treiber, T.]]
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[[Category: Treiber, T]]
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[[Category: Zocher, G.]]
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[[Category: Zocher, G]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Helix-loop-helix]]
[[Category: Helix-loop-helix]]

Revision as of 15:21, 24 December 2014

Early B-cell Factor 1 (Ebf1) bound to DNA

3mlp, resolution 2.80Å

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