3mtn

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mtn RCSB], [http://www.ebi.ac.uk/pdbsum/3mtn PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mtn RCSB], [http://www.ebi.ac.uk/pdbsum/3mtn PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/UBP21_HUMAN UBP21_HUMAN]] Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.<ref>PMID:10799498</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 15:23, 24 December 2014

Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor

3mtn, resolution 2.70Å

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