1sr4
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1sr4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_ducreyi Haemophilus ducreyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SR4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1sr4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_ducreyi Haemophilus ducreyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SR4 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDTA, HD0902 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=730 Haemophilus ducreyi])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDTA, HD0902 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=730 Haemophilus ducreyi])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sr4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sr4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sr4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sr4 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CDTA_HAEDU CDTA_HAEDU]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for the delivery of CdtB. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Haemophilus ducreyi]] | [[Category: Haemophilus ducreyi]] | ||
| - | [[Category: Hsu, Y | + | [[Category: Hsu, Y]] |
| - | [[Category: Nesic, D | + | [[Category: Nesic, D]] |
| - | [[Category: Stebbins, C E | + | [[Category: Stebbins, C E]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Bacterial]] | [[Category: Bacterial]] | ||
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[[Category: Dna damage]] | [[Category: Dna damage]] | ||
[[Category: Genotoxin]] | [[Category: Genotoxin]] | ||
| - | [[Category: Haemophilus ducreyi]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
[[Category: Virulence]] | [[Category: Virulence]] | ||
Revision as of 15:27, 24 December 2014
Crystal Structure of the Haemophilus ducreyi cytolethal distending toxin
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Categories: Haemophilus ducreyi | Hsu, Y | Nesic, D | Stebbins, C E | Apoptosis | Bacterial | Cell cycle | Cytotoxin | Deoxyribonuclease i | Dna damage | Genotoxin | Lectin | Toxin | Virulence
