2vwg
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vwg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloferax_mediterranei Haloferax mediterranei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VWG FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vwg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloferax_mediterranei Haloferax mediterranei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VWG FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LGC:(3S,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-ONE'>LGC</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LGC:(3S,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-ONE'>LGC</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vwq|2vwq]], [[2b5w|2b5w]], [[2b5v|2b5v]], [[2vwh|2vwh]], [[2vwp|2vwp]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vwq|2vwq]], [[2b5w|2b5w]], [[2b5v|2b5v]], [[2vwh|2vwh]], [[2vwp|2vwp]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vwg RCSB], [http://www.ebi.ac.uk/pdbsum/2vwg PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vwg RCSB], [http://www.ebi.ac.uk/pdbsum/2vwg PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q977U7_HALME Q977U7_HALME]] Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-xylose, D-galactose, and D-fucose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a preference for NADP(+). Physiologically, seems to be involved in the degradation of glucose through a modified Entner-Doudoroff pathway.<ref>PMID:11425479</ref> <ref>PMID:8925901</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Glucose 1-dehydrogenase]] | [[Category: Glucose 1-dehydrogenase]] | ||
[[Category: Haloferax mediterranei]] | [[Category: Haloferax mediterranei]] | ||
| - | [[Category: Baker, P J | + | [[Category: Baker, P J]] |
| - | [[Category: Bonete, M J | + | [[Category: Bonete, M J]] |
| - | [[Category: Britton, K L | + | [[Category: Britton, K L]] |
| - | [[Category: Esclapez, J | + | [[Category: Esclapez, J]] |
| - | [[Category: Ferrer, J | + | [[Category: Ferrer, J]] |
| - | [[Category: Fisher, M | + | [[Category: Fisher, M]] |
| - | [[Category: Pire, C | + | [[Category: Pire, C]] |
| - | [[Category: Rice, D W | + | [[Category: Rice, D W]] |
[[Category: Alcohol dehydrogenase]] | [[Category: Alcohol dehydrogenase]] | ||
[[Category: Glucose dehydrogenase]] | [[Category: Glucose dehydrogenase]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Zinc dependent medium chain alcohol dehydrogenase family]] | [[Category: Zinc dependent medium chain alcohol dehydrogenase family]] | ||
Revision as of 15:28, 24 December 2014
HALOFERAX MEDITERRANEI GLUCOSE DEHYDROGENASE IN COMPLEX WITH NADP, ZN AND GLUCONOLACTONE.
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