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3jwp

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jwp RCSB], [http://www.ebi.ac.uk/pdbsum/3jwp PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jwp RCSB], [http://www.ebi.ac.uk/pdbsum/3jwp PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/Q8IE47_PLAF7 Q8IE47_PLAF7]] NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.<ref>PMID:15820676</ref> <ref>PMID:17827348</ref> <ref>PMID:18729382</ref> <ref>PMID:18397290</ref> <ref>PMID:18525026</ref> <ref>PMID:18221799</ref> <ref>PMID:19402747</ref> <ref>PMID:20601220</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Revision as of 15:29, 24 December 2014

Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP

3jwp, resolution 2.65Å

Drag the structure with the mouse to rotate

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