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1xod
From Proteopedia
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| - | [[Image:1xod.gif|left|200px]] | + | [[Image:1xod.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of X. tropicalis Spred1 EVH-1 domain''' | + | {{Structure |
| + | |PDB= 1xod |SIZE=350|CAPTION= <scene name='initialview01'>1xod</scene>, resolution 1.15Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= Spred1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8364 Xenopus tropicalis]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of X. tropicalis Spred1 EVH-1 domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XOD is a [ | + | 1XOD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOD OCA]. |
==Reference== | ==Reference== | ||
| - | 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:[http:// | + | 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15710406 15710406] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Xenopus tropicalis]] | [[Category: Xenopus tropicalis]] | ||
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[[Category: sprouty]] | [[Category: sprouty]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:27 2008'' |
Revision as of 13:12, 20 March 2008
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| , resolution 1.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Spred1 (Xenopus tropicalis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of X. tropicalis Spred1 EVH-1 domain
Overview
The recently described Spred protein family has been implicated in the modulation of receptor tyrosine kinase signalling. We report the crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution. This structure confirms that the Spred EVH1 adopts the pleckstrin-homology fold, with a similar secondary structure to Enabled. A translation of one of the peptide-binding groove beta-strands narrows this groove, whilst one end of the groove shows structural flexibility. We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit.
About this Structure
1XOD is a Single protein structure of sequence from Xenopus tropicalis. Full crystallographic information is available from OCA.
Reference
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:15710406
Page seeded by OCA on Thu Mar 20 15:12:27 2008
Categories: Single protein | Xenopus tropicalis | Amaya, E. | Blundell, T L. | Harmer, N J. | Sivak, J M. | GOL | Evh1 | Peptide-binding | Spred | Sprouty
