1xod

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[[Image:1xod.gif|left|200px]]<br /><applet load="1xod" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1xod.gif|left|200px]]
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caption="1xod, resolution 1.15&Aring;" />
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'''Crystal structure of X. tropicalis Spred1 EVH-1 domain'''<br />
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{{Structure
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|PDB= 1xod |SIZE=350|CAPTION= <scene name='initialview01'>1xod</scene>, resolution 1.15&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE= Spred1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8364 Xenopus tropicalis])
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}}
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'''Crystal structure of X. tropicalis Spred1 EVH-1 domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1XOD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOD OCA].
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1XOD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOD OCA].
==Reference==
==Reference==
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1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15710406 15710406]
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1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15710406 15710406]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Xenopus tropicalis]]
[[Category: Xenopus tropicalis]]
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[[Category: sprouty]]
[[Category: sprouty]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:56:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:27 2008''

Revision as of 13:12, 20 March 2008

Image:1xod.gif


PDB ID 1xod

Drag the structure with the mouse to rotate
, resolution 1.15Å
Ligands:
Gene: Spred1 (Xenopus tropicalis)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of X. tropicalis Spred1 EVH-1 domain


Overview

The recently described Spred protein family has been implicated in the modulation of receptor tyrosine kinase signalling. We report the crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution. This structure confirms that the Spred EVH1 adopts the pleckstrin-homology fold, with a similar secondary structure to Enabled. A translation of one of the peptide-binding groove beta-strands narrows this groove, whilst one end of the groove shows structural flexibility. We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit.

About this Structure

1XOD is a Single protein structure of sequence from Xenopus tropicalis. Full crystallographic information is available from OCA.

Reference

1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:15710406

Page seeded by OCA on Thu Mar 20 15:12:27 2008

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