1xok
From Proteopedia
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| - | [[Image:1xok.gif|left|200px]] | + | [[Image:1xok.gif|left|200px]] |
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| - | '''crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide''' | + | {{Structure |
| + | |PDB= 1xok |SIZE=350|CAPTION= <scene name='initialview01'>1xok</scene>, resolution 3.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=BR:BROMIDE ION'>BR</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XOK is a [ | + | 1XOK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOK OCA]. |
==Reference== | ==Reference== | ||
| - | Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication., Guogas LM, Filman DJ, Hogle JM, Gehrke L, Science. 2004 Dec 17;306(5704):2108-11. PMID:[http:// | + | Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication., Guogas LM, Filman DJ, Hogle JM, Gehrke L, Science. 2004 Dec 17;306(5704):2108-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15604410 15604410] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Filman, D J.]] | [[Category: Filman, D J.]] | ||
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[[Category: protein-rna complex]] | [[Category: protein-rna complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:30 2008'' |
Revision as of 13:12, 20 March 2008
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| , resolution 3.00Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide
Overview
Alfalfa mosaic virus genomic RNAs are infectious only when the viral coat protein binds to the RNA 3' termini. The crystal structure of an alfalfa mosaic virus RNA-peptide complex reveals that conserved AUGC repeats and Pro-Thr-x-Arg-Ser-x-x-Tyr coat protein amino acids cofold upon interacting. Alternating AUGC residues have opposite orientation, and they base pair in different adjacent duplexes. Localized RNA backbone reversals stabilized by arginine-guanine interactions place the adenosines and guanines in reverse order in the duplex. The results suggest that a uniform, organized 3' conformation, similar to that found on viral RNAs with transfer RNA-like ends, may be essential for replication.
About this Structure
1XOK is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication., Guogas LM, Filman DJ, Hogle JM, Gehrke L, Science. 2004 Dec 17;306(5704):2108-11. PMID:15604410
Page seeded by OCA on Thu Mar 20 15:12:30 2008
