1xr0

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[[Image:1xr0.gif|left|200px]]<br /><applet load="1xr0" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1xr0.gif|left|200px]]
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caption="1xr0" />
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'''Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors'''<br />
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{{Structure
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|PDB= 1xr0 |SIZE=350|CAPTION= <scene name='initialview01'>1xr0</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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'''Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1XR0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XR0 OCA].
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1XR0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XR0 OCA].
==Reference==
==Reference==
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Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors., Dhalluin C, Yan KS, Plotnikova O, Lee KW, Zeng L, Kuti M, Mujtaba S, Goldfarb MP, Zhou MM, Mol Cell. 2000 Oct;6(4):921-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11090629 11090629]
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Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors., Dhalluin C, Yan KS, Plotnikova O, Lee KW, Zeng L, Kuti M, Mujtaba S, Goldfarb MP, Zhou MM, Mol Cell. 2000 Oct;6(4):921-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11090629 11090629]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: trk]]
[[Category: trk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:57:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:13:26 2008''

Revision as of 13:13, 20 March 2008

Image:1xr0.gif


PDB ID 1xr0

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Coordinates: save as pdb, mmCIF, xml



Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors


Contents

Overview

SNT adaptor proteins transduce activation of fibroblast growth factor receptors (FGFRs) and neurotrophin receptors (TRKs) to common signaling targets. The SNT-1 phosphotyrosine binding (PTB) domain recognizes activated TRKs at a canonical NPXpY motif and, atypically, binds to nonphosphorylated FGFRs in a region lacking tyrosine or asparagine. Here, using NMR and mutational analyses, we show that the PTB domain utilizes distinct sets of amino acid residues to interact with FGFRs or TRKs in a mutually exclusive manner. The FGFR1 peptide wraps around the beta sandwich structure of the PTB domain, and its binding is possibly regulated by conformational change of a unique C-terminal beta strand in the protein. Our results suggest mechanisms by which SNTs serve as molecular switches to mediate the essential interplay between FGFR and TRK signaling during neuronal differentiation.

Disease

Known diseases associated with this structure: Atopic dermatitis, susceptibility to OMIM:[135940], Ichthyosis vulgaris OMIM:[135940], Jackson-Weiss syndrome OMIM:[136350], Kallmann syndrome 2 OMIM:[136350], Pfeiffer syndrome OMIM:[136350]

About this Structure

1XR0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors., Dhalluin C, Yan KS, Plotnikova O, Lee KW, Zeng L, Kuti M, Mujtaba S, Goldfarb MP, Zhou MM, Mol Cell. 2000 Oct;6(4):921-9. PMID:11090629

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