1u9n
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1u9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9N FirstGlance]. <br> | <table><tr><td colspan='2'>[[1u9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9N FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CNS:HEXADECYL+OCTANOATE'>CNS</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CNS:HEXADECYL+OCTANOATE'>CNS</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u9o|1u9o]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u9o|1u9o]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9n RCSB], [http://www.ebi.ac.uk/pdbsum/1u9n PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9n RCSB], [http://www.ebi.ac.uk/pdbsum/1u9n PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/P96222_MYCTU P96222_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 31: | Line 33: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: Baulard, A R | + | [[Category: Baulard, A R]] |
| - | [[Category: Engohang-Ndong, J | + | [[Category: Engohang-Ndong, J]] |
| - | [[Category: Frenois, F | + | [[Category: Frenois, F]] |
| - | [[Category: Locht, C | + | [[Category: Locht, C]] |
| - | [[Category: Villeret, V | + | [[Category: Villeret, V]] |
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Protein-ligand complex]] | [[Category: Protein-ligand complex]] | ||
[[Category: Tetr family]] | [[Category: Tetr family]] | ||
[[Category: Transcriptional repressor]] | [[Category: Transcriptional repressor]] | ||
Revision as of 16:00, 24 December 2014
Crystal structure of the transcriptional regulator EthR in a ligand bound conformation opens therapeutic perspectives against tuberculosis and leprosy
| |||||||||||
