3hil
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hil OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hil RCSB], [http://www.ebi.ac.uk/pdbsum/3hil PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hil OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hil RCSB], [http://www.ebi.ac.uk/pdbsum/3hil PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EPHA1_HUMAN EPHA1_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.<ref>PMID:17634955</ref> <ref>PMID:19118217</ref> <ref>PMID:20043122</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 21: | Line 23: | ||
==See Also== | ==See Also== | ||
*[[Ephrin receptor|Ephrin receptor]] | *[[Ephrin receptor|Ephrin receptor]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 16:07, 24 December 2014
SAM Domain of Human Ephrin Type-A Receptor 1 (EphA1)
| |||||||||||
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Arrowsmith, C H | Bochkarev, A | Bountra, C | Butler-Cole, C | Dhe-Paganon, S | Edwards, A M | Structural genomic | Walker, J R | Weigelt, J | Yermekbayeva, L | Atp-binding | Glycoprotein | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Receptor | Sgc | Sterile alpha motif | Transferase | Transmembrane | Tyrosine-protein kinase
