2by4

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2by4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BY4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2by4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BY4 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=AD4:(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL+12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE'>AD4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=AD4:(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL+12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE'>AD4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fqu|1fqu]], [[1iwo|1iwo]], [[1kju|1kju]], [[1su4|1su4]], [[1t5s|1t5s]], [[1t5t|1t5t]], [[1vfp|1vfp]], [[1wpe|1wpe]], [[1wpg|1wpg]], [[1xp5|1xp5]], [[2agv|2agv]], [[2c88|2c88]], [[2c8k|2c8k]], [[2c8l|2c8l]], [[2c9m|2c9m]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fqu|1fqu]], [[1iwo|1iwo]], [[1kju|1kju]], [[1su4|1su4]], [[1t5s|1t5s]], [[1t5t|1t5t]], [[1vfp|1vfp]], [[1wpe|1wpe]], [[1wpg|1wpg]], [[1xp5|1xp5]], [[2agv|2agv]], [[2c88|2c88]], [[2c8k|2c8k]], [[2c8l|2c8l]], [[2c9m|2c9m]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2by4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2by4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2by4 RCSB], [http://www.ebi.ac.uk/pdbsum/2by4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2by4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2by4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2by4 RCSB], [http://www.ebi.ac.uk/pdbsum/2by4 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Calcium-transporting ATPase]]
[[Category: Calcium-transporting ATPase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Christensen, S B.]]
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[[Category: Christensen, S B]]
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[[Category: Denmeade, S R.]]
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[[Category: Denmeade, S R]]
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[[Category: Isaacs, J T.]]
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[[Category: Isaacs, J T]]
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[[Category: Jensen, A L.]]
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[[Category: Jensen, A L]]
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[[Category: Moller, J V.]]
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[[Category: Moller, J V]]
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[[Category: Nissen, P.]]
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[[Category: Nissen, P]]
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[[Category: Olsen, C E.]]
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[[Category: Olsen, C E]]
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[[Category: Soehoel, H.]]
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[[Category: Soehoel, H]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Ca2+-atpase]]
[[Category: Ca2+-atpase]]

Revision as of 16:08, 24 December 2014

SR CA(2+)-ATPASE IN THE HNE2 STATE COMPLEXED WITH THE THAPSIGARGIN DERIVATIVE BOC-12ADT.

2by4, resolution 3.30Å

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OCA

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