1xwv
From Proteopedia
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| - | [[Image:1xwv.gif|left|200px]] | + | [[Image:1xwv.gif|left|200px]] |
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| - | '''Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity''' | + | {{Structure |
| + | |PDB= 1xwv |SIZE=350|CAPTION= <scene name='initialview01'>1xwv</scene>, resolution 1.83Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene> and <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XWV is a [ | + | 1XWV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWV OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity., Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M, FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:[http:// | + | Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity., Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M, FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15710415 15710415] |
[[Category: Dermatophagoides farinae]] | [[Category: Dermatophagoides farinae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: PE3]] | [[Category: PE3]] | ||
[[Category: XPE]] | [[Category: XPE]] | ||
| - | [[Category: beta | + | [[Category: beta sheet]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:15:32 2008'' |
Revision as of 13:15, 20 March 2008
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| , resolution 1.83Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity
Overview
The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.
About this Structure
1XWV is a Single protein structure of sequence from Dermatophagoides farinae. Full crystallographic information is available from OCA.
Reference
Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity., Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M, FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415
Page seeded by OCA on Thu Mar 20 15:15:32 2008
