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2pi0
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pi0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pi0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pi0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pi0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pi0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pi0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IRF3_HUMAN IRF3_HUMAN]] Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Aggarwal, A K | + | [[Category: Aggarwal, A K]] |
| - | [[Category: Escalante, C R | + | [[Category: Escalante, C R]] |
| - | [[Category: Garcia-Sastre, A | + | [[Category: Garcia-Sastre, A]] |
| - | [[Category: Leyi, S | + | [[Category: Leyi, S]] |
| - | [[Category: Nistal-Villan, E | + | [[Category: Nistal-Villan, E]] |
[[Category: Interferon]] | [[Category: Interferon]] | ||
[[Category: Protein-dna complex]] | [[Category: Protein-dna complex]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription activator-dna complex]] | [[Category: Transcription activator-dna complex]] | ||
Revision as of 16:23, 24 December 2014
Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer
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