1y00
From Proteopedia
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| - | [[Image:1y00.gif|left|200px]] | + | [[Image:1y00.gif|left|200px]] |
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| - | '''Solution structure of the Carbon Storage Regulator protein CsrA''' | + | {{Structure |
| + | |PDB= 1y00 |SIZE=350|CAPTION= <scene name='initialview01'>1y00</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of the Carbon Storage Regulator protein CsrA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Y00 is a [ | + | 1Y00 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the carbon storage regulator protein CsrA from Escherichia coli., Gutierrez P, Li Y, Osborne MJ, Pomerantseva E, Liu Q, Gehring K, J Bacteriol. 2005 May;187(10):3496-501. PMID:[http:// | + | Solution structure of the carbon storage regulator protein CsrA from Escherichia coli., Gutierrez P, Li Y, Osborne MJ, Pomerantseva E, Liu Q, Gehring K, J Bacteriol. 2005 May;187(10):3496-501. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15866937 15866937] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: carbon storage regulation]] | [[Category: carbon storage regulation]] | ||
[[Category: montreal-kingston bacterial structural genomics initiative]] | [[Category: montreal-kingston bacterial structural genomics initiative]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:16:43 2008'' |
Revision as of 13:16, 20 March 2008
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| Gene: | csrA (Escherichia coli) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the Carbon Storage Regulator protein CsrA
Overview
The carbon storage regulator A (CsrA) is a protein responsible for the repression of a variety of stationary-phase genes in bacteria. In this work, we describe the nuclear magnetic resonance (NMR)-based structure of the CsrA dimer and its RNA-binding properties. CsrA is a dimer of two identical subunits, each composed of five strands, a small alpha-helix and a flexible C terminus. NMR titration experiments suggest that the beta1-beta2 and beta3-beta4 loops and the C-terminal helix are important elements in RNA binding. Even though the beta3-beta4 loop contains a highly conserved RNA-binding motif, GxxG, typical of KH domains, our structure excludes CsrA from being a member of this protein family, as previously suggested. A mechanism for the recognition of mRNAs downregulated by CsrA is proposed.
About this Structure
1Y00 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Solution structure of the carbon storage regulator protein CsrA from Escherichia coli., Gutierrez P, Li Y, Osborne MJ, Pomerantseva E, Liu Q, Gehring K, J Bacteriol. 2005 May;187(10):3496-501. PMID:15866937
Page seeded by OCA on Thu Mar 20 15:16:43 2008
