1y0h

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[[Image:1y0h.gif|left|200px]]<br /><applet load="1y0h" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1y0h.gif|left|200px]]
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caption="1y0h, resolution 1.600&Aring;" />
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'''Structure of Rv0793 from Mycobacterium tuberculosis'''<br />
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{{Structure
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|PDB= 1y0h |SIZE=350|CAPTION= <scene name='initialview01'>1y0h</scene>, resolution 1.600&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACT:ACETATE ION'>ACT</scene>
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|ACTIVITY=
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|GENE= Rv0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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}}
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'''Structure of Rv0793 from Mycobacterium tuberculosis'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Y0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0H OCA].
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1Y0H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0H OCA].
==Reference==
==Reference==
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The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16496224 16496224]
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The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16496224 16496224]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: tb structural genomics consortium]]
[[Category: tb structural genomics consortium]]
[[Category: tbsgc]]
[[Category: tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:00:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:16:53 2008''

Revision as of 13:16, 20 March 2008

Image:1y0h.gif


PDB ID 1y0h

Drag the structure with the mouse to rotate
, resolution 1.600Å
Ligands:
Gene: Rv0793 (Mycobacterium tuberculosis)
Coordinates: save as pdb, mmCIF, xml



Structure of Rv0793 from Mycobacterium tuberculosis


Overview

Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.

About this Structure

1Y0H is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:16496224

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