2m32

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{{STRUCTURE_2m32| PDB=2m32 | SCENE= }}
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==Alpha-1 integrin I-domain in complex with GLOGEN triple helical peptide==
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===Alpha-1 integrin I-domain in complex with GLOGEN triple helical peptide===
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<StructureSection load='2m32' size='340' side='right' caption='[[2m32]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_24187131}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2m32]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M32 FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITGA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m32 RCSB], [http://www.ebi.ac.uk/pdbsum/2m32 PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/ITA1_HUMAN ITA1_HUMAN]] Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
[[http://www.uniprot.org/uniprot/ITA1_HUMAN ITA1_HUMAN]] Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the structure of the human integrin alpha1I domain bound to a triple-helical collagen peptide. The structure of the alpha1I-peptide complex was investigated using data from NMR, small angle x-ray scattering, and size exclusion chromatography that were used to generate and validate a model of the complex using the data-driven docking program, HADDOCK (High Ambiguity Driven Biomolecular Docking). The structure revealed that the alpha1I domain undergoes a major conformational change upon binding of the collagen peptide. This involves a large movement in the C-terminal helix of the alphaI domain that has been suggested to be the mechanism by which signals are propagated in the intact integrin receptor. The structure suggests a basis for the different binding selectivity observed for the alpha1I and alpha2I domains. Mutational data identify residues that contribute to the conformational change observed. Furthermore, small angle x-ray scattering data suggest that at low collagen peptide concentrations the complex exists in equilibrium between a 1:1 and 2:1 alpha1I-peptide complex.
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The structure of integrin alpha1I domain in complex with a collagen-mimetic peptide.,Chin YK, Headey SJ, Mohanty B, Patil R, McEwan PA, Swarbrick JD, Mulhern TD, Emsley J, Simpson JS, Scanlon MJ J Biol Chem. 2013 Dec 27;288(52):36796-809. doi: 10.1074/jbc.M113.480251. Epub, 2013 Nov 1. PMID:24187131<ref>PMID:24187131</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[2m32]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M32 OCA].
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</div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:024187131</ref><references group="xtra"/><references/>
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*[[Integrin|Integrin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Chin, Y.]]
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[[Category: Chin, Y]]
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[[Category: Emsley, J.]]
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[[Category: Emsley, J]]
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[[Category: Headey, S.]]
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[[Category: Headey, S]]
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[[Category: McEwan, P.]]
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[[Category: McEwan, P]]
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[[Category: Mohanty, B.]]
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[[Category: Mohanty, B]]
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[[Category: Mulhern, T.]]
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[[Category: Mulhern, T]]
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[[Category: Scanlon, M.]]
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[[Category: Scanlon, M]]
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[[Category: Simpson, J.]]
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[[Category: Simpson, J]]
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[[Category: Swarbrick, J.]]
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[[Category: Swarbrick, J]]
[[Category: Alpha-1 integrin]]
[[Category: Alpha-1 integrin]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Glogen]]
[[Category: Glogen]]
[[Category: I-domain]]
[[Category: I-domain]]

Revision as of 16:43, 24 December 2014

Alpha-1 integrin I-domain in complex with GLOGEN triple helical peptide

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