4hjj
From Proteopedia
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| - | + | ==Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule== | |
| - | + | <StructureSection load='4hjj' size='340' side='right' caption='[[4hjj]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4hjj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJJ FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vxv|2vxv]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL18, IGIF, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hjj RCSB], [http://www.ebi.ac.uk/pdbsum/4hjj PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. | [[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Several bispecific antibody-based formats have been developed over the past 25 years in an effort to produce a new generation of immunotherapeutics that target two or more disease mechanisms simultaneously. One such format, the dual-variable domain immunoglobulin (DVD-Ig), combines the target binding domains of two monoclonal antibodies via flexible naturally occurring linkers, which yields a tetravalent IgG - like molecule. We report the structure of an interleukin (IL)12-IL18 DVD-Ig Fab (DFab) fragment with IL18 bound to the inner variable domain (VD) that reveals the remarkable flexibility of the DVD-Ig molecule and how the DVD-Ig format can function to bind four antigens simultaneously. An understanding of how the inner variable domain retains function is of critical importance for designing DVD-Ig molecules, and for better understanding of the flexibility of immunoglobulin variable domains and linkers, which may aid in the design of improved bi- and multi-specific biologics in general. | ||
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| + | Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig) molecule.,Jakob CG, Edalji R, Judge RA, Digiammarino E, Li Y, Gu J, Ghayur T MAbs. 2013 Apr 2;5(3). PMID:23549062<ref>PMID:23549062</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Interleukin|Interleukin]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: DiGiammarino, E | + | [[Category: DiGiammarino, E]] |
| - | [[Category: Edalji, R | + | [[Category: Edalji, R]] |
| - | [[Category: Ghayur, T | + | [[Category: Ghayur, T]] |
| - | [[Category: Gu, J | + | [[Category: Gu, J]] |
| - | [[Category: Jakob, C G | + | [[Category: Jakob, C G]] |
| - | [[Category: Judge, R A | + | [[Category: Judge, R A]] |
| - | [[Category: Li, Y | + | [[Category: Li, Y]] |
[[Category: Dfab complex]] | [[Category: Dfab complex]] | ||
[[Category: Dual variable domain immunoglobulin]] | [[Category: Dual variable domain immunoglobulin]] | ||
[[Category: Il-18]] | [[Category: Il-18]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
Revision as of 16:50, 24 December 2014
Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule
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