4u2m
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u2m RCSB], [http://www.ebi.ac.uk/pdbsum/4u2m PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u2m RCSB], [http://www.ebi.ac.uk/pdbsum/4u2m PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZBT17_HUMAN ZBT17_HUMAN]] Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.<ref>PMID:9312026</ref> <ref>PMID:9308237</ref> <ref>PMID:19164764</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 16:57, 24 December 2014
Crystal structure of a complex of the Miz1- and BCL6 POZ domains.
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