3smr

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3smr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMR FirstGlance]. <br>
<table><tr><td colspan='2'>[[3smr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NP7:2-CHLORO-N-[2-(4-METHYLPIPERAZIN-1-YL)-5-NITROPHENYL]BENZAMIDE'>NP7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NP7:2-CHLORO-N-[2-(4-METHYLPIPERAZIN-1-YL)-5-NITROPHENYL]BENZAMIDE'>NP7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3smr RCSB], [http://www.ebi.ac.uk/pdbsum/3smr PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3smr RCSB], [http://www.ebi.ac.uk/pdbsum/3smr PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Al-Awar, R.]]
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[[Category: Al-Awar, R]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bolshan, Y.]]
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[[Category: Bolshan, Y]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Brown, P J.]]
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[[Category: Brown, P J]]
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[[Category: Dombrovski, L.]]
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[[Category: Dombrovski, L]]
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[[Category: Dong, A.]]
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[[Category: Dong, A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Hajian, T.]]
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[[Category: Hajian, T]]
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[[Category: Nguyen, K T.]]
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[[Category: Nguyen, K T]]
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[[Category: Poda, G.]]
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[[Category: Poda, G]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schapira, M.]]
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[[Category: Senisterra, G.]]
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[[Category: Smil, D.]]
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[[Category: Tempel, W.]]
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[[Category: Vedadi, M.]]
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[[Category: Wasney, G A.]]
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[[Category: Weigelt, J.]]
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[[Category: Wu, H.]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Schapira, M]]
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[[Category: Senisterra, G]]
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[[Category: Smil, D]]
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[[Category: Tempel, W]]
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[[Category: Vedadi, M]]
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[[Category: Wasney, G A]]
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[[Category: Weigelt, J]]
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[[Category: Wu, H]]
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[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Wd repeat domain 5]]
[[Category: Wd repeat domain 5]]
[[Category: Wdr5]]
[[Category: Wdr5]]

Revision as of 17:13, 24 December 2014

Crystal structure of human WD repeat domain 5 with compound

3smr, resolution 1.82Å

Drag the structure with the mouse to rotate

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OCA

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