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3tfj
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3tfj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candidatus_pelagibacter_ubique Candidatus pelagibacter ubique]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[3tfj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candidatus_pelagibacter_ubique Candidatus pelagibacter ubique]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFJ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tfh|3tfh]], [[3tfi|3tfi]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tfh|3tfh]], [[3tfi|3tfi]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dmdA, SAR11_0246 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198252 Candidatus Pelagibacter ubique])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dmdA, SAR11_0246 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198252 Candidatus Pelagibacter ubique])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminomethyltransferase Aminomethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.10 2.1.2.10] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminomethyltransferase Aminomethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.10 2.1.2.10] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tfj RCSB], [http://www.ebi.ac.uk/pdbsum/3tfj PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tfj RCSB], [http://www.ebi.ac.uk/pdbsum/3tfj PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q4FP21_PELUB Q4FP21_PELUB]] Major contributor to the demethylation of dimethlysulfonioproprionate (DMSP). Demethylates DMSP to methyl-mercaptopropionate (MMPA).<ref>PMID:17068264</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism pelagabacter ubique.,Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN Protein Sci. 2011 Dec 7. doi: 10.1002/pro.2015. PMID:22162093<ref>PMID:22162093</ref> | Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism pelagabacter ubique.,Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN Protein Sci. 2011 Dec 7. doi: 10.1002/pro.2015. PMID:22162093<ref>PMID:22162093</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Aminomethyltransferase]] | [[Category: Aminomethyltransferase]] | ||
[[Category: Candidatus pelagibacter ubique]] | [[Category: Candidatus pelagibacter ubique]] | ||
| - | [[Category: Lanzilotta, W N | + | [[Category: Lanzilotta, W N]] |
| - | [[Category: Moran, M A | + | [[Category: Moran, M A]] |
| - | [[Category: Reisch, C R | + | [[Category: Reisch, C R]] |
| - | [[Category: Schuller, D J | + | [[Category: Schuller, D J]] |
| - | [[Category: Whitman, W B | + | [[Category: Whitman, W B]] |
[[Category: Demethylase]] | [[Category: Demethylase]] | ||
[[Category: Thf]] | [[Category: Thf]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 17:28, 24 December 2014
DMSP-dependent demethylase from P. ubique - with cofactor THF
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