2l76
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [http://www.ebi.ac.uk/pdbsum/2l76 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [http://www.ebi.ac.uk/pdbsum/2l76 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN]] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 17:39, 24 December 2014
Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto
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Categories: Homo sapiens | Arrowsmith, C H | Dhe-Paganon, S | Doherty, R | Houliston, S | Structural genomic | OCSP, Ontario Centre for Structural Proteomics | Semesi, A | Wu, B | Yee, A | Nesg | Ocsp | Ontario centre for structural proteomic | PSI, Protein structure initiative | Psi-biology | Transcription | Ubiquitin-like domain
