1dll
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dll RCSB], [http://www.ebi.ac.uk/pdbsum/1dll PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dll RCSB], [http://www.ebi.ac.uk/pdbsum/1dll PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 17:42, 24 December 2014
The HC fragement of tetanus toxin complexed with lactose
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Categories: Clostridium tetani | Tentoxilysin | Black, I | Charles, I G | Emsley, P | Fairweather, N F | Fotinou, C | Hewitt, E | Isaacs, N W | Watts, C | Beta trefoil | Jelly roll | Toxin
