3rnj

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[[Image:3rnj.png|left|200px]]
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==Crystal structure of the SH3 domain from IRSp53 (BAIAP2)==
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<StructureSection load='3rnj' size='340' side='right' caption='[[3rnj]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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{{STRUCTURE_3rnj| PDB=3rnj | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNJ FirstGlance]. <br>
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===Crystal structure of the SH3 domain from IRSp53 (BAIAP2)===
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAIAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rnj RCSB], [http://www.ebi.ac.uk/pdbsum/3rnj PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[3rnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNJ OCA].
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== Function ==
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[[http://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Barilari, M.]]
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[[Category: Barilari, M]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad, A]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Dente, L.]]
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[[Category: Dente, L]]
[[Category: Edwards, A M]]
[[Category: Edwards, A M]]
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[[Category: Feller, S M.]]
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[[Category: Feller, S M]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos, P]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz, J R.C]]
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[[Category: Raynor, J.]]
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[[Category: Raynor, J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Simister, P C.]]
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[[Category: Simister, P C]]
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[[Category: Tregubova, A.]]
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[[Category: Tregubova, A]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar, M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Proline-rich motif]]
[[Category: Proline-rich motif]]
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[[Category: Protein interaction domain]]
[[Category: Protein interaction domain]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 

Revision as of 17:46, 24 December 2014

Crystal structure of the SH3 domain from IRSp53 (BAIAP2)

3rnj, resolution 1.50Å

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