1yho
From Proteopedia
(Difference between revisions)
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| - | [[Image:1yho.gif|left|200px]]< | + | [[Image:1yho.gif|left|200px]] |
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| - | '''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures''' | + | {{Structure |
| + | |PDB= 1yho |SIZE=350|CAPTION= <scene name='initialview01'>1yho</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures''' | ||
| + | |||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YHO is a [ | + | 1YHO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHO OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:[http:// | + | Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16222560 16222560] |
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: inhibitor/enzyme complex]] | [[Category: inhibitor/enzyme complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:22:59 2008'' |
Revision as of 13:23, 20 March 2008
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| Ligands: | and | ||||||
| Activity: | Dihydrofolate reductase, with EC number 1.5.1.3 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Disease
Known disease associated with this structure: Anemia, megaloblastic, due to DHFR deficiency (1) OMIM:[126060]
About this Structure
1YHO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:16222560
Page seeded by OCA on Thu Mar 20 15:22:59 2008
