2qzf
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qzf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qzf RCSB], [http://www.ebi.ac.uk/pdbsum/2qzf PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qzf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qzf RCSB], [http://www.ebi.ac.uk/pdbsum/2qzf PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bowman, V D | + | [[Category: Bowman, V D]] |
| - | [[Category: Chipman, P R | + | [[Category: Chipman, P R]] |
| - | [[Category: Hafenstein, S | + | [[Category: Hafenstein, S]] |
| - | [[Category: Kelly, C M.Bator | + | [[Category: Kelly, C M.Bator]] |
| - | [[Category: Lin, F | + | [[Category: Lin, F]] |
| - | [[Category: Medof, M E | + | [[Category: Medof, M E]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
[[Category: Blood group antigen]] | [[Category: Blood group antigen]] | ||
[[Category: Complement pathway]] | [[Category: Complement pathway]] | ||
Revision as of 17:48, 24 December 2014
SCR1 of DAF from 1ojv fitted into cryoEM density
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Categories: Homo sapiens | Bowman, V D | Chipman, P R | Hafenstein, S | Kelly, C M.Bator | Lin, F | Medof, M E | Rossmann, M G | Blood group antigen | Complement pathway | Glycoprotein | Gpi-anchor | Immune response | Immune system | Innate immunity | Lipoprotein | Membrane | Scr1 of daf from structure 1ojv fitted into cryoem density | Sushi
