1yjx
From Proteopedia
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| - | [[Image:1yjx.gif|left|200px]] | + | [[Image:1yjx.gif|left|200px]] |
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| - | '''Crystal structure of human B type phosphoglycerate mutase''' | + | {{Structure |
| + | |PDB= 1yjx |SIZE=350|CAPTION= <scene name='initialview01'>1yjx</scene>, resolution 2.800Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of human B type phosphoglycerate mutase''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YJX is a [ | + | 1YJX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJX OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of human B-type phosphoglycerate mutase bound with citrate., Wang Y, Wei Z, Liu L, Cheng Z, Lin Y, Ji F, Gong W, Biochem Biophys Res Commun. 2005 Jun 17;331(4):1207-15. PMID:[http:// | + | Crystal structure of human B-type phosphoglycerate mutase bound with citrate., Wang Y, Wei Z, Liu L, Cheng Z, Lin Y, Ji F, Gong W, Biochem Biophys Res Commun. 2005 Jun 17;331(4):1207-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15883004 15883004] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: alpha/beta]] | [[Category: alpha/beta]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:23:50 2008'' |
Revision as of 13:23, 20 March 2008
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| , resolution 2.800Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human B type phosphoglycerate mutase
Overview
The B-type cofactor-dependent phosphoglycerate mutase (dPGM-B) catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in glycolysis and gluconeogenesis pathways using 2,3-bisphosphoglycerate as the cofactor. The crystal structures of human dPGM-B bound with citrate were determined in two crystal forms. These structures reveal a dimerization mode conserved in both of dPGM and BPGM (bisphosphoglycerate mutase), based on which a dPGM/BPGM heterodimer structure is proposed. Structural comparison supports that the conformational changes of residues 13-21 and 98-117 determine PGM/BPGM activity differences. The citrate-binding mode suggests a substrate-binding model, consistent with the structure of Escherichia coli dPGM/vanadate complex. A chloride ion was found in the center of the dimer, providing explanation for the contribution of chloride ion to dPGM activities. Based on the structural information, the possible reasons for the deficient human dPGM mutations found in some patients are also discussed.
About this Structure
1YJX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human B-type phosphoglycerate mutase bound with citrate., Wang Y, Wei Z, Liu L, Cheng Z, Lin Y, Ji F, Gong W, Biochem Biophys Res Commun. 2005 Jun 17;331(4):1207-15. PMID:15883004
Page seeded by OCA on Thu Mar 20 15:23:50 2008
Categories: Homo sapiens | Single protein | Gong, W. | Liu, L. | Wang, Y. | Wei, Z. | CIT | CL | Alpha/beta
