4anm
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4anm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ANM FirstGlance]. <br> | <table><tr><td colspan='2'>[[4anm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ANM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WUL:8-BROMANYL-2-[[(3S)-3-OXIDANYLPYRROLIDIN-1-YL]METHYL]-3H-[1]BENZOFURO[3,2-D]PYRIMIDIN-4-ONE'>WUL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WUL:8-BROMANYL-2-[[(3S)-3-OXIDANYLPYRROLIDIN-1-YL]METHYL]-3H-[1]BENZOFURO[3,2-D]PYRIMIDIN-4-ONE'>WUL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1daw|1daw]], [[1day|1day]], [[1ds5|1ds5]], [[1f0q|1f0q]], [[1j91|1j91]], [[1jam|1jam]], [[1lp4|1lp4]], [[1lpu|1lpu]], [[1lr4|1lr4]], [[1m2p|1m2p]], [[1m2q|1m2q]], [[1m2r|1m2r]], [[1om1|1om1]], [[1zoe|1zoe]], [[1zog|1zog]], [[1zoh|1zoh]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1daw|1daw]], [[1day|1day]], [[1ds5|1ds5]], [[1f0q|1f0q]], [[1j91|1j91]], [[1jam|1jam]], [[1lp4|1lp4]], [[1lpu|1lpu]], [[1lr4|1lr4]], [[1m2p|1m2p]], [[1m2q|1m2q]], [[1m2r|1m2r]], [[1om1|1om1]], [[1zoe|1zoe]], [[1zog|1zog]], [[1zoh|1zoh]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4anm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4anm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4anm RCSB], [http://www.ebi.ac.uk/pdbsum/4anm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4anm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4anm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4anm RCSB], [http://www.ebi.ac.uk/pdbsum/4anm PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSK2A_MAIZE CSK2A_MAIZE]] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Discovery of XL413, a potent and selective CDC7 inhibitor.,Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. Epub 2012 Apr 16. PMID:22560567<ref>PMID:22560567</ref> | Discovery of XL413, a potent and selective CDC7 inhibitor.,Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. Epub 2012 Apr 16. PMID:22560567<ref>PMID:22560567</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
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[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Zea mays]] | [[Category: Zea mays]] | ||
| - | [[Category: Stout, T J | + | [[Category: Stout, T J]] |
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 17:57, 24 December 2014
Complex of CK2 with a CDC7 inhibitor
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