1ykb

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[[Image:1ykb.gif|left|200px]]<br /><applet load="1ykb" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ykb.gif|left|200px]]
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caption="1ykb, resolution 2.60&Aring;" />
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'''Crystal Structure of Insect Cell Expressed IL-22'''<br />
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{{Structure
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|PDB= 1ykb |SIZE=350|CAPTION= <scene name='initialview01'>1ykb</scene>, resolution 2.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY=
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|GENE= IL22, ILTIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of Insect Cell Expressed IL-22'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].
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1YKB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].
==Reference==
==Reference==
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Structure of insect-cell-derived IL-22., Xu T, Logsdon NJ, Walter MR, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15983417 15983417]
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Structure of insect-cell-derived IL-22., Xu T, Logsdon NJ, Walter MR, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15983417 15983417]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: interleukin]]
[[Category: interleukin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:24:02 2008''

Revision as of 13:24, 20 March 2008

Image:1ykb.gif


PDB ID 1ykb

Drag the structure with the mouse to rotate
, resolution 2.60Å
Ligands:
Gene: IL22, ILTIF (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Insect Cell Expressed IL-22


Overview

The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.

About this Structure

1YKB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of insect-cell-derived IL-22., Xu T, Logsdon NJ, Walter MR, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417

Page seeded by OCA on Thu Mar 20 15:24:02 2008

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