1yks

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1yks.gif|left|200px]]<br /><applet load="1yks" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1yks.gif|left|200px]]
-
caption="1yks, resolution 1.8&Aring;" />
+
 
-
'''Crystal structure of yellow fever virus NS3 helicase'''<br />
+
{{Structure
 +
|PDB= 1yks |SIZE=350|CAPTION= <scene name='initialview01'>1yks</scene>, resolution 1.8&Aring;
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91]
 +
|GENE=
 +
}}
 +
 
 +
'''Crystal structure of yellow fever virus NS3 helicase'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1YKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Active as [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKS OCA].
+
1YKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKS OCA].
==Reference==
==Reference==
-
Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16051820 16051820]
+
Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16051820 16051820]
[[Category: Flavivirin]]
[[Category: Flavivirin]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 25: Line 34:
[[Category: yellow fever virus]]
[[Category: yellow fever virus]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:21 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:24:08 2008''

Revision as of 13:24, 20 March 2008


PDB ID 1yks

Drag the structure with the mouse to rotate
, resolution 1.8Å
Activity: Flavivirin, with EC number 3.4.21.91
Coordinates: save as pdb, mmCIF, xml



Crystal structure of yellow fever virus NS3 helicase


Overview

Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.

About this Structure

1YKS is a Single protein structure of sequence from Yellow fever virus. Full crystallographic information is available from OCA.

Reference

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820

Page seeded by OCA on Thu Mar 20 15:24:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools